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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Does High AMA Level Suggest?

TOTAL TRIIODOTHYRONINE (T3) 95 ng/dl TOTAL THYROXINE (T4)9.4 micro gm/dl THYROID STIMULATING HORMONE (TSH) ). 8.35 μIU/ml FREE TRIIODOTHYRONINE (FT3). 3.13pg/ml FREE THYROXINE (FT4)1.19 ng/dl ANTI MICROSOMAL ANTIBODY (AMA. 484IU/mL Hello Doctor I am very worried regarding my thyroid test which was done recently . I was wondering if you could give me an expert opinion on my report . I have attached it for you. I am planning for a baby very soon . Do I need to be worried about my AMA levels .? I have come across literature which indicates that high AMA levels are associated with sub fertility. . Do I need some kind of treatment before planning pregnancy. Eagerly waiting for your reply. Many Thanks
Fri, 21 Feb 2014
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Endocrinologist 's  Response
Hi Dear,

It is not clear if you are taking thyroid medications now. If not, the blood tests shows that you have a condition called Subclinical Hypothyroidism where as your TSH alone is elevated. The high Anti Microsomal antibody ( also called as Anti TPO) suggests that it is an auto immune condition ( hashimotos).

You are right in that, there is evidence that high levels of Anti microsomal antibodies have been found to be associated with sub fertility and pregnancy loss. But not to worry, there chances are low.

In your case, as you are wanting to have a baby soon, it is wise to start on Thyroxine replacement. This is a very safe drug and doesn't have adverse effects on pregnancy, but instead, has good effects. YOU NEED TO KEEP YOUR TSH < 2.5 BEFORE PREGNANCY AND IN THE FIRST THREE MONTHS of pregnancy. Meet your endocrinologist and they can discuss further.
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What Does High AMA Level Suggest?

Hi Dear, It is not clear if you are taking thyroid medications now. If not, the blood tests shows that you have a condition called Subclinical Hypothyroidism where as your TSH alone is elevated. The high Anti Microsomal antibody ( also called as Anti TPO) suggests that it is an auto immune condition ( hashimotos). You are right in that, there is evidence that high levels of Anti microsomal antibodies have been found to be associated with sub fertility and pregnancy loss. But not to worry, there chances are low. In your case, as you are wanting to have a baby soon, it is wise to start on Thyroxine replacement. This is a very safe drug and doesn t have adverse effects on pregnancy, but instead, has good effects. YOU NEED TO KEEP YOUR TSH 2.5 BEFORE PREGNANCY AND IN THE FIRST THREE MONTHS of pregnancy. Meet your endocrinologist and they can discuss further.