Hello, thanks for writing in. I have read your query, where you have mentioned two new spots on the xray, which I assume are on the bone, and not the soft tissue. In order to diagnose a bone lesion on Xray, it is important to know the shape, margins, exact location , whether it is white/black etc. There are a list of possibilities including benign & malignant bone tumors, metastases, infarcts, and other tumor mimics to be considered. Also, if the reason for the knee replacement is degeneration in the joint, the spots maybe related to the same process. In the absence of imaging details, I would recommend you consult a doctor who can read the xray as well as provide pain medication for your husband. Hope this is helpful. Do write in again with any doubts. Take care.