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Dr. Andrew Rynne

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What could the reason for my recurring miscarriages when all the investigations show normal reports ?

Recurrent Miscarriages - Hello, I am 30 years old female. I am married for 4 years. Currently i had my third miscarriage. Apart from this i also had on Medical Termination of my Pregnancy(first pregnancy) in 20 weeks because of Hypoplastic Right heart syndrome for the baby. My miscarriages happens in between 8th 1oth week of pregnancy. I have done with chromosome testing for me and my husband, karyotyping of my first fetus was also done, antibodies testing, was treated with aspirin and heparin injection also. All the tests show me the result that i am normal. But unable to find the reason for my recurrent miscarriages.......Please help me to find identify the reason and solve the proble. Thanks in advance Hello, I am 30 years old female. I am married for 4 years. Currently i had my third miscarriage. Apart from this i also had on Medical Termination of my Pregnancy(first pregnancy) in 20 weeks because of Hypoplastic Right heart syndrome for the baby. My miscarriages happens in between 8th to 1oth week of pregnancy. I have done with chromosome testing for me and my husband, karyotyping of my first fetus was also done, antibodies testing(APTT & Antiphospolipid), was treated with aspirin(75mg) and heparin injection(20mg-Once in a day) also. All the tests show me the result that i am normal. But unable to find the reason for my recurrent miscarriages.......Please help me to find identify the reason and solve the proble. Thanks in advance
Fri, 13 Jan 2012
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OBGYN 's  Response
Hello.
Thanks for choosing HealthcareMagic forum.
In most of the cases recurrent abortions in first three months do not have any reason other than chromosomal defects in the baby not compatible with life. There is no treatment for this and there is no use of worrying too much. All the investigations will not reveal anything. Just pray to God that next time you get a good result.
Dr. Rakhi Tayal
drrakhitayal@gmail.com


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doctor1 MD

History : My sister (Age 32) under gone three repeated miscarriages • First miscarriage happened in 2nd month • Second miscarriage happened in 4th month • Third miscarriage happened in 4th month After third miscarriage we undergone some of the tests suggested by the doctor and below are the details Date : 28 July 2010 Tests undergone first time after three miscarriages Lupus Anticoagulant 1 (Screen) 53 sec (Normal 28-45) Lupus Anticoagulant 2 (confirm) 58 sec (Normal 28-40) Ratio (LA1/LA2) 0.91 ( 1.3 Normal) A.P.T.T TEST 38 sec (result) (Normal 30-40 sec) CONTROL 24 sec (result) (Normal 30-40 sec) ANTI CORDIOLIPIN ANTIBODIES CARDIOLIPIN ANTIBODY – lgM 9.67 PL-lgM-U/mL ( 10 : Negative) CARDIOLIPIN ANTIBODY – lgG 28.0 PL-lgG-U/mL ( 10 : Negative, 10-20 LOW POSITIVE 20-40 MODERATE POSITIVE) CARDIOLIPIN ANTIBODY – lgA 13.27 PL-lgA-U/mL ( 10 : Negative 10-20 LOW POSITIVE) PROLACTIN (PRL) 11.67 ng/ml (Result) (Normal Range ; Females Non-Pregnant: 2.8 – 29.2) Thyroid Stimulating Hormone ( TSH ) 1.06 ulU/mL (Result) (Normal Range 0.34-5.60 ulU/mL) FSH 6.17 mIU/mL (Result) (Normal Range (Normal Range Femal Follicular phase 2.5-10.2) Date : 28 September 2010 After 2 months medication repeated below tests Lupus Anticoagulant 1 (Screen) 32 sec (Normal 28-45) Lupus Anticoagulant 2 (confirm) 36 sec (Normal 28-40) Ratio (LA1/LA2) 0.88 ( 1.3 Normal) A.P.T.T TEST 27 sec (result) (Normal 30-40 sec) CONTROL 24 sec (result) (Normal 30-40 sec) ANTI CORDIOLIPIN ANTIBODIES CARDIOLIPIN ANTIBODY – lgM 8.71 PL-lgM-U/mL ( 10 : Negative) CARDIOLIPIN ANTIBODY – lgG 10.9 PL-lgG-U/mL ( 10 : Negative, 10-20 LOW POSITIVE ) CARDIOLIPIN ANTIBODY – lgA 7.26 PL-lgA-U/mL ( 10 : Negative) Date : 10 January 2011 Found that my sister is affected with TB undergone 6 months course for TB Date : 17 May 2011 Suggested Laproscopic surgery for better findings, after laproscopic surgery below is the discharge summary Recurrent Pregnancy loss for evaluation Operative Hysteroscopy & Laparoscopy done on 17 May 2011 At Hysteroscopy: • Both ostia visualized normally placed • Uterine cavity normal At Laparoscopy: • Uterus normal size • Both tubes normal. Dye test positive both sides. • Small fimbrial cyst present on test tube, excised. • Both overies polycystic, ovarian drilling done • POD free, No E/O adhesions or endometriosis Biopsy result Nature of Specimen: Endometrial Curettings for HPE Microscopic Examination: Sections revealed endometrial tissue with predominantly blood clots and few glands in proliferative pattern. No evidence of neoplasia or granulomas Impression: Proliferative pattern What I want to say: After three miscarriages my sister undergone above tests and some test results were not in normal range, after two months medication those readings came to normal range. And upon our request for any tests Dr. went for Laproscopic surgery and said that she has done ovarian drilling and uterus condition is good and biopsy says that TB which attacked my sister doesn’t have any effect on her uterus. And Dr also says that we need to go Ecosprin and Loprin (not sure of the correct names) injections continously till 9th month once after conceived What I want to ask: There was no specifc finding from Dr that this was the reason for 3 repeated miscarriages, to the best of my knowledge except karotyping we have completed all tests. I am seeking your suggestion in case we are missing any other tests and will be there any side affects of taking daily injections for 9months and any other suggestions/advice are invited. Our whole intension is not to have another miscarriage. Thanks in Advance

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