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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Could Be The Cause For Elevated CA125 Blood Test Reading?

Our daughter was admitted to A& E suffering from severe abdominal pain She had a Laparoscopy, before her the result of her CA125 blood test result was back and next day when it arrived it was elevated to 1123. Surgeon also got histology result from laparoscopy which showed no Cancer and no endometriosis ,but surgeon said she had grade4 endometriosis, failed to carry out a recommended MRI scan" to asses the cystic lesions" on her ovaries on 3rd day of her stay in hospital. She was prescribed Decapeptyl and Livial for Endometriosis, and discharged. She suffered shooting pains in her abdomen, night sweats and lower back pain. Surgeon continued to assure her that she had a benigh serous adenoma for next 3 months and refused to do any further tests. She believed him that her symptoms were consistant with the prescription which fed ovarian cancer which was diagnosed 4 months later. She was 34 years and after referral to a centre of excellence where she had radical surgery and invasive treatment she died. We believe she was misdiagnosed and high reading from CA125 blood test should not have been ignored. Cancer was not ruled out, and a transvaginal- interuterine scan was not done, it was just an ultra sound that showed up an ovarian cyst. Surgeon obviously didn't know the implications of an extremely high reading from CA125 test, which can be elevated for a number of reasons, we know but cancer should have been ruled out,as she had 3 cases of breast cancer and one of ovarian /stomach cancer in family history too close to her. Where can we get a top specialist who would be willing to research her case, and how much would it cost. Our daughter was never sick in her life, except for asthma, which she got under control.
Wed, 5 Feb 2014
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Pathologist and Microbiologist 's  Response
Hello and welcome to HCM,
It is very sad to know that your daughter died because of ovarian cancer.
The levels of CA 125 are raised in number of conditions.
However, ovarian cancer is the most common cause of raised CA 125.
In ovarian cancer, the level of CA 125 is very much raised.
Endometriosis is also a cause of raised CA 125 levels.
The ovarian cancer could have been serous cystadenoma to begin with and the adenoma could have developed into cancer over a period of time.
It is possible for serous adenoma to develop into cancer and the raised CA 125 level could have been due to endometriosis.
I don't know when any investigation s possible after her death.
You will have to look for an oncologist dealing specifically with gynecological malignancies.

Thanks and take care
Dr Shailja P Wahal
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What Could Be The Cause For Elevated CA125 Blood Test Reading?

Hello and welcome to HCM, It is very sad to know that your daughter died because of ovarian cancer. The levels of CA 125 are raised in number of conditions. However, ovarian cancer is the most common cause of raised CA 125. In ovarian cancer, the level of CA 125 is very much raised. Endometriosis is also a cause of raised CA 125 levels. The ovarian cancer could have been serous cystadenoma to begin with and the adenoma could have developed into cancer over a period of time. It is possible for serous adenoma to develop into cancer and the raised CA 125 level could have been due to endometriosis. I don t know when any investigation s possible after her death. You will have to look for an oncologist dealing specifically with gynecological malignancies. Thanks and take care Dr Shailja P Wahal