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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Vertigo And Drowsiness While On Primidone?

I have recently started taking primidone 250mg 3 times a day for treatment of shaking. I started at a much lower dose but it was not really effective. The higher dose does seem to be more effective however I am having issues with balance and drowsiness. I also have COPD and this may be causing some related breathing issues
Tue, 2 Jan 2018
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General & Family Physician 's  Response
hello sir,
first of all primidone is an anti seizure medication. you should be sure that you are suffering from a seizure disorder before starting this drug.as you said you also have COPD and if you are using inhaler drugs for COPD symptoms (beta agonists like albuteral, salbutamol) , they have a side effect of causing tremors. so make sure it's not tremors and it's a seizure disorder.
then coming to primidone it's known to cause vertigo and ataxia even sedation sometimes. that's why it's not much preferred by most of the clinicians nowadays ( as the are much better drugs like carbamazepine and more are available now).
primidone will not cause any breathing problems.

it's too exhaustive if I start explaining the mechanism behind these side effects. but I will try to give you a brief idea. the reason why people suffer from seizures is due to hyperexcitability of their nervous system. so these drugs are used to suppress this hyperexcitability and sometimes it causes suppression of normal excitations which leads to side effects like sedation , vertigo and gait disturbances which actually depends on nervous system excitations. so modern drugs are developed which are more specific for these hyperexcitability neuron pathways and not affiliated affecting the normal ones. hope this information helps you.
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What Causes Vertigo And Drowsiness While On Primidone?

hello sir, first of all primidone is an anti seizure medication. you should be sure that you are suffering from a seizure disorder before starting this drug.as you said you also have COPD and if you are using inhaler drugs for COPD symptoms (beta agonists like albuteral, salbutamol) , they have a side effect of causing tremors. so make sure it s not tremors and it s a seizure disorder. then coming to primidone it s known to cause vertigo and ataxia even sedation sometimes. that s why it s not much preferred by most of the clinicians nowadays ( as the are much better drugs like carbamazepine and more are available now). primidone will not cause any breathing problems. it s too exhaustive if I start explaining the mechanism behind these side effects. but I will try to give you a brief idea. the reason why people suffer from seizures is due to hyperexcitability of their nervous system. so these drugs are used to suppress this hyperexcitability and sometimes it causes suppression of normal excitations which leads to side effects like sedation , vertigo and gait disturbances which actually depends on nervous system excitations. so modern drugs are developed which are more specific for these hyperexcitability neuron pathways and not affiliated affecting the normal ones. hope this information helps you.