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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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    What causes sudden weight loss and loss of appetite?

I have very high TSH (68), free T4 is 1.16, which is in the normal range. I have persistent weight loss, lack of appetite. Today I vomited twice. I have a extramedullary plasmacytoma in my gum. Biopsy said CD 79A and Lambda were strongly positive, CD 138, Cd 3 and Kappa were focally positive in a small number of cells, CD 20 was negative. Radiation therapy scheduled for tomorrow was put off so I could get another biopsy. MRI, PET, CT scans bone marrow test show no cancer cells anywhere. The growth in my gum was painful and swollen when I got my first biopsy, but how it only looks different , is not swollen and without pain. I am taking Keppra to prevent seizures, have started prilosec 6 days ago to reduce GERD. I am a 78 year old male. I am trying to make an appointment with an endocronologist. Heart and many other tests are normal Should I be doing anything else? T3 and other blood test results have not arrived yet. Protein electrophoresis shows polyclonal gammopathy. I am slightly anemic and have some osteoporosis according to bone density scan.
Mon, 10 Dec 2018
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Internal Medicine Specialist 's  Response
Hello,

An extramedullary plasmacytoma may be treated with radiotherapy only. But in few patients may be combined with surgery.

The local tumour may recurrent after radiation is only 10%. Hyperthyroidism may cause weight gain or in few patients, it may present like secondary to brain and lung.

Please consult your oncologist he will examine and treat you according to the stage of disease and your health condition.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Penchila Prasad Kandikattu , Internal Medicine Specialist
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