Hi! Good afternoon. I am Dr Shareef answering your query. The lump on your ankle might not be related to your Crohn s disease if you exert chronic pressure on that location of your ankle inadvertently. This could result in a benign cyst called a bursa, which might also be related to the joint cavity. However, this could also be a manifestation of the extra intestinal manifestation of the Crohn s disease. I would advise you to get it clinically assessed along with related investigations by your treating doctor, and this would depend its further course of action, if need be. Till that, you could go for a mild anti inflammatory drug along with a proton pump inhibitor drug for a symptomatic relief of the pain. I hope this information would help you in discussing with your family physician/treating doctor in further management of your problem. Please do not hesitate to ask in case of any further doubts. Thanks for choosing health care magic to clear doubts on your health problems. I wish you an early recovery. Dr Shareef.