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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Severe Diarrhea While On Creon?

Hello, Doctor!! I had Whipple Reconstruction on Nov.2,2017. The surgeon just prescribed me Famotidine to take twice a day. I lost a lot of weight and experiencing I had a Whipple Reconstruction in November of 2016. The pancreatic tumor is not cancerous. The GI doctor prescribed 36,000 units of Creon for me to take, two capsules each meal and one every snack. a total of 8 capsules a day. She gave me a sample bottle of Creon to try. On the third day I felt so sick at night and vomited a lot and non-stop diarrhea. The next day, I was fine. I stopped taking those Creon and had not experienced episodes of diarrhea for almost a month. Is there any substitute for Creon?
Wed, 13 Sep 2017
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General Surgeon,  's  Response
Hi.
Thanks for your query.
Noted the history and understood your concerns.
Whipples surgery involves removing pancreas and the structures nearby hence the problem of weight loss has to come in and hence needs regular follow up and adjustment of medications, foods and beverages ; lifestyle changes and so on.
Creon is a combination of pancreatic enzymes most needed for digestion of the food that you take.
Since you developed loose stools after three days of taking creon, I do not think it is creon that caused the problems.
You may please start with creon in reduced dosages of one capsule with food and then slowly increase the dosages or better adjust as per the response that you intestines give.
Alternatives are there and your Doctor can tell you the best available in your area.
Also identify the foods and beverages that instigate or enhance the problems and you will be fine avoiding the ones that cause you the problems.
Also needed may be insulin as the pancreas has been removed, get blood sugar done.
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What Causes Severe Diarrhea While On Creon?

Hi. Thanks for your query. Noted the history and understood your concerns. Whipples surgery involves removing pancreas and the structures nearby hence the problem of weight loss has to come in and hence needs regular follow up and adjustment of medications, foods and beverages ; lifestyle changes and so on. Creon is a combination of pancreatic enzymes most needed for digestion of the food that you take. Since you developed loose stools after three days of taking creon, I do not think it is creon that caused the problems. You may please start with creon in reduced dosages of one capsule with food and then slowly increase the dosages or better adjust as per the response that you intestines give. Alternatives are there and your Doctor can tell you the best available in your area. Also identify the foods and beverages that instigate or enhance the problems and you will be fine avoiding the ones that cause you the problems. Also needed may be insulin as the pancreas has been removed, get blood sugar done.