Hello, the differential diagnosis of thoracic pain is rather broad but needs careful evaluation because it relates to serious medical conditions. All doctors know that and since your wife visited the hospital it would be very unusual if she had something serious and left undiagnosed. You haven t provided enough information about her pain, so I could not give you a complete answer but I ll try to give you an idea. Pain caused by coronary artery disease usually feels like tightness on the center of the chest, it is sometimes accompanied by nausea (or vomiting) and may radiate to the left shoulder, neck or the back. Pericarditis (abnormal fluid accumulation around the heart) causes pain with breathing movements. Pulmonary embolism may cause pain with breathing movements too but its most prominent symptom is shortness of breath. These are some of the most important diagnoses which all could be excluded accurately enough with an electrocardiogram and blood tests like d-dimers, troponin (negative troponin 6 hours after the pain started excludes myocardial infarction). These tests are readily available and I would be very surprised if your doctors did not order them. I m sure they did and the results were OK. Thoracic pain has many benign causes as well. One of the most common is psychological stress. Many individuals feel pain when under stress. This pain is usually different from the pain of coronary artery disease or other organic conditions and a doctor would characterize it as atypical , which means that the pain attributes like time of onset, duration, etc cannot be recognized as a specific pattern. I hope I ve given you some insight about your wife s situation. If you need further clarifications please ask again, providing more information about her pain and the tests she s done so far. If your question has been answered, please rate my answer and send me a thanks if you re satisfied. Kind Regards!