Hi, Thanks for the query.I understand your concern. The numbness your friend hpas in two middle toes of foot seem to be due to trauma or pinching of nerve supplying the toes.This could be due to- - bony pressure due to it s swelling at any joint level (knee,ankle,toe joints ,boney sour ) -Tarsal tunnel syndrome. -pinching pf nerve due to umber spine or disc ptoblem. MRI would help in pin pointing the cause followed y specific treatment. (Anti inflammatory pills,local steroid injection,physiotherapy,surgery. ) He should consult an oethopedic doctor. Thanks.