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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Muscle Cramps Post GnRH Analogue Shot For Endometriosis?

I had my LSCS done in Nov 2013. After a couple of months was diagnosed of endometriosis. I have been given GnRH analogue injection to start the treatment for the same. Took my 1st one on 15th march 2016 and ever since that day I m experiencing muscle cramps in both my legs and heaviness too. Is that a side effect ? What treatment for it now?
Mon, 25 Apr 2016
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General & Family Physician,  's  Response
Hi,
Thanks for posting in HCM.
I understand your concern.
Gonadotropin-releasing hormone agonist (GnRH analogue) is a synthetic peptide that have been used to treat women with endometriosis for many years.
When used continuously for periods of longer than 2 weeks, they stop the production of estrogen by a series of mechanisms. Most women will stop bleeding within 2 months of starting treatment.
The side effects of the GnRH analogues are largely the result of the low levels of estrogen in the body. Most common side effects experienced include: insomnia, decreased libido, headache, mood swings, vaginal dryness, variation in breast size, acne, muscle pains, dizziness and depression.
Muscular symptoms what you are experiencing could be due to side effects of the medication and you need to take symptomatic treatment for that. Gradually, it should stabilize and you should be relieved of such symptoms.
Hope the information provided would be helpful.
All the best.
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What Causes Muscle Cramps Post GnRH Analogue Shot For Endometriosis?

Hi, Thanks for posting in HCM. I understand your concern. Gonadotropin-releasing hormone agonist (GnRH analogue) is a synthetic peptide that have been used to treat women with endometriosis for many years. When used continuously for periods of longer than 2 weeks, they stop the production of estrogen by a series of mechanisms. Most women will stop bleeding within 2 months of starting treatment. The side effects of the GnRH analogues are largely the result of the low levels of estrogen in the body. Most common side effects experienced include: insomnia, decreased libido, headache, mood swings, vaginal dryness, variation in breast size, acne, muscle pains, dizziness and depression. Muscular symptoms what you are experiencing could be due to side effects of the medication and you need to take symptomatic treatment for that. Gradually, it should stabilize and you should be relieved of such symptoms. Hope the information provided would be helpful. All the best.