I ve had cataract surgery on one eye. The moment I began using prednisolone eye drops, I experienced mood changes, nervousness and hives. I had anger issues also. All not there beforehand. Dr. switched me to Lotemax, but now I m waking up in middle of nite and can t go back to sleep, along with mood changes, nervousness and anger,. The hives seem to have gotten much better. I seem to have severe allergic reactions to a lot of drugs, but is this still possible using the eye drops.??