Hi and thanks for sharing your question with us at HCM. Thank you for providing a detailed history. You have had quite an eventful obstetrics history which has led up to tubal ligation. I am sorry that you have lost a baby. You have had yeast infections which suggest insulin resistance and impaired sugar metabolism. You also mention that there is family history of various types of cancer. Are these estrogen-driven cancers like breast, ovarian and uterine cancers? The pain you mentioned could be from an impending period that has been long-delayed. Menstrual cycles can become irregular when there is hormonal imbalance. As you probably already know, there are two major female hormones; estrogen and progesterone. Both have to be in balance for normal female functioning. Estrogen is produced by the ovaries, adrenals and fat cells. Xenoestrogens are estrogens which come from external sources - detergents, cosmetics, plastic cookware, meat etc. all contain xenoestrogens. Progesterone is produced by the ovaries as well - it has numerous functions in the body and one of them is to keep estrogen in balance. Another common hormone disorder that can lead to menstrual irregularities is hypothyroidism (under-active thyroid). Symptoms of hypothyroidism include weight gain, difficulty losing weight, decreased appetite, lethargy, dry skin and hair loss. In a young lady such as yourself, a common cause of menstrual irregularity is estrogen dominance. In estrogen dominance, there is too little, normal or excess estrogen but there is insufficient progesterone to balance it. Women who are overweight tend to have more problems with their period because fat cells produce estrogen as well and the excess estrogen upsets the menstrual cycle. Xenoestrogens coming into the body add to the excess estrogen. The history that you have provided suggest that you may be overweight (hence the impaired sugar tolerance) and may have estrogen dominance. Other symptoms of estrogen dominance include significant PMS, headaches, fatigue, fat deposition around the abdomen, hips and thighs, emotional lability, poor memory and even thyroid dysfunction. Unchecked estrogen dominance can lead to breast, uterine and ovarian cancers in women. If this applies to you, please take note of your dietary habits and lifestyle. Eat clean - especially cut off sugar to end the vicious cycle of insulin resistance. Try to incorporate regular exercise. I recommend that you see your regular doctor, discuss the possibility of hormonal imbalance with them and have them examine you and weigh you. Please get them to do a full blood test including: 1. TSH, free T3 and T4 to rule out thyroid issues 2. Female hormone panel 3. Blood sugar, insulin levels and HbA1c. 4. Lipid profile 5. Kidney and liver profiles 6. CA 125 tumor marker if there is family history of ovarian disease Also have them perform an ultrasound to visualize the uterus and ovaries. This is to measure the endometrial lining of the uterus to gauge which part of the menstrual cycle you are currently in as well as to rule out any problems with the ovaries. I hope this has answered your question satisfactorily. Good luck Dr Shabnam