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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Hypothyroidism Symptoms Despite A Normal TSH Level?

Have all the symptoms of hypothyroidism but TSH was normal. Sent to an internal specialist who ran more tests. Anti-inflammatory markers high but other tests did not show Lupus or rheumatoid arthritis. Diagnosed me with Fibro and said to take Lyrica. Went to naturalpath as I did not like the answers. She did more blood work . Anti thyroid antibodies should be 0-35 and mine are 397.7. My estrogen level is 348 while my progesterone level is 17 (believe they should be balanced or near one another). It has been a 20 year struggle- 6 pregnancies, 2 miscarriages, early age for hysterectomy, constant migraines, all the symptoms of a thyroid issue, etc. I need another opinion because now I am stuck between the doctor and the naturalpath. Suggestions?
Mon, 2 Jul 2018
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Endocrinologist 's  Response
Hello and welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

Your anti-thyroid antibodies are high and this is suggestive of an thyroid autoimmune disease. In my opinion your diagnosis is Hashimoto's thyroiditis. This is the most common cause of hypothyroidism. In Hashimoto's thyroiditis, the body mounts an immune reaction against its own thyroid gland tissue, leading to inflammation of the gland (thyroiditis) and the gradual destruction of the gland. The reference range of estradiol and progesterone in women varies by menstrual cycle and menopausal status. Your results are compatible with periovulatory levels and in my opinion, these are not cause of your actual symptoms. My suggestion is to repeat the thyroid tests: TSH, fT3, and fT4 because you are at risk for hypothyroidism (because of Hashimoto's). In these circumstances, it is necessary to verify your actual thyroid gland function because if you actually have low thyroid hormones,your body may need thyroid hormone replacement therapy.

Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Elona Xhardo
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What Causes Hypothyroidism Symptoms Despite A Normal TSH Level?

Hello and welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Your anti-thyroid antibodies are high and this is suggestive of an thyroid autoimmune disease. In my opinion your diagnosis is Hashimoto s thyroiditis. This is the most common cause of hypothyroidism. In Hashimoto s thyroiditis, the body mounts an immune reaction against its own thyroid gland tissue, leading to inflammation of the gland (thyroiditis) and the gradual destruction of the gland. The reference range of estradiol and progesterone in women varies by menstrual cycle and menopausal status. Your results are compatible with periovulatory levels and in my opinion, these are not cause of your actual symptoms. My suggestion is to repeat the thyroid tests: TSH, fT3, and fT4 because you are at risk for hypothyroidism (because of Hashimoto s). In these circumstances, it is necessary to verify your actual thyroid gland function because if you actually have low thyroid hormones,your body may need thyroid hormone replacement therapy. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Elona Xhardo