Thank you for your query. Based on your query, I gather that you are a hypertensive and have cardiac disease. You are also on medications to lower your cholesterol. Hypertension, heart disease, and high cholesterol levels need to be regularly monitored and medications/dosages adjusted to bring in tight control. Your are currently on medications to reduce blood pressure, cholesterol lowering agents and anti angina medications (for the heart). Your blood pressure seems to be poorly controlled on the current regimen. I recommend you see your physician to change the regimen and see what suits you best. It will take a couple of months to settle on to a suitable treatment plan and needs to be monitored at regular intervals. Nicardia reduces the blood pressure and is dose dependent. You see a fall in pressure for as long as the effect lasts and then it goes up again. Resistance to medications (when your body doesn t respond, as expected, to the medicine when taken for a period of time) also gives rise to poor efficiency. Fluctuations or high blood pressure can lead to stroke, heart failure. If you experience any breathing difficulty, chest pain, giddiness, slurred speech, muscle weakness or numbness, unusual forgetfulness, please visit the ER right away. Ideally your blood pressure should be between 120-140 (systolic) and 75-85(diastolic), heart rate between 60-70 beats per minute. Hope I ve convinced you on the importance of seeing your physician as soon as you can Hope this helps.. Wish you good health. Please feel free to contact us if you need further clarification