Yes, as of May 2012 I started a series of Synthroid @ 50mcg, then upped to 75 mcg then back down to 50 mcg with unchanged symptoms of fatigue, chills, weight gain, and an unbalanced TSH, T3 or T4 levels. Recently, by the way I m am 61 years old and taking Pantonase and generic Flonaise for sinues, I began to get dry mouth with metal or acid taste only during sleep. My tongue sticks to my palatte. If I tilt my head, my salivary glands are activated. Since I have a spinal condition, I sleep with a wedged pillow under my knees and with this taste , started using a wedged pillow for my upper back to keep possible stomach acids from entering my throat. Still am fatigued, more so, chills, dry mouth with metalic, etc. Keep in mind that I took Synthroid at the ages of 5-7, 2years after my daughter was born, I was 30, and recently after turn 61. I m always on a low caloric diet. The sinus issues started.when I was 21 and subsequent treatments since, so no changes except the combination of Flonase and Patonase and Synthroid. Could the dry mouth be the combination of medications or a more serious illness? I m not a heart patient, although my mother had issues, I m at 29% body fat, and have spurts of energy. My job is very stressful on the phones 8 to 12 hours/ day with electric utility customers.