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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Enlarged Liver With High Bilirubin Levels?

Hi my husband is diagnosed with bipolar, diabetes and in his past has used drugs. Recently he became jaundice and his ammonia and bilirubin levels are very high 18. His docs have taken him off most of his meds including depakote and Seroquel. His tests for Hep A B and C have come back negative but his ultrasound shows his liver is inflamed or enlarged. What could possibly be the diagnosis. Also his urine was very dark but recently has begun to lighten up. Any help would be appreciated.
Mon, 29 Feb 2016
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Gastroenterologist,  's  Response
Hello! Thanks for putting your query in HCM. I am a Gastroenterologist.

Enlarged liver has many cause like Hepatitis B, C, Metabolic disorders, NAFLD, alcohol intake etc. Although Hepatitis B and C are negative as you have mentioned. It may be due to diabetes also.So I will suggest you to visit a Hepatologist for evaluation who will advise tests and then manage accordingly.

Meanwhile there are few medicines which I found very useful in my patients are ursodeoxycholic acid and vitamin E. Ask him to do regular exercise and reduce his weight if he is overweight, avoid alcohol if he drink.

I hope I have answered your query and this will help you . Wish you a good health
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What Causes Enlarged Liver With High Bilirubin Levels?

Hello! Thanks for putting your query in HCM. I am a Gastroenterologist. Enlarged liver has many cause like Hepatitis B, C, Metabolic disorders, NAFLD, alcohol intake etc. Although Hepatitis B and C are negative as you have mentioned. It may be due to diabetes also.So I will suggest you to visit a Hepatologist for evaluation who will advise tests and then manage accordingly. Meanwhile there are few medicines which I found very useful in my patients are ursodeoxycholic acid and vitamin E. Ask him to do regular exercise and reduce his weight if he is overweight, avoid alcohol if he drink. I hope I have answered your query and this will help you . Wish you a good health