i m kathleen - i have a negative result on my c-kit mutation test. however my dr wants a 2nd opinion from a university setting as he calls it. i have other health issues and terminal arterial pulmonary hypertension as well as a genetic blood clotting disorder and enlarged right side of my heart. i don t want any more black clouds over my head as i live my life thus far with a good quality thanks to my current therapies. i m not sure if i want to pursue possibly more terminal issues. my tryptase value is 19 in 2-10 range and immunoglubulin E 125 in a range of less than 125. i appreciate his concern re possible anaphylaxis and he mentions this is over his head and may require a bone marrow biopsy. this only started when i met him as an allergist to see if i m allergic to calamari as a result of 2 instances i experienced. his testing was extensive and there s not one for my issue. but he elected to do these last 2 labs and this is where i m at. i don t like to be overwhelmed by info on the internet where i saw possible connections with cancer when looking at possible diagnoses under the description of tryptase on my lab result. thanks for listening....kathleen