For the first 3 days, side effects were limited to dry mouth. However, on the 4th and 5th days of taking Amitrityline, 10 mg, in the evening before bedtime, I experiences a significant dry mouth followed by a reaction involving my throat and upper chest on both sides. This reaction was quite severe and involved discomfort and some difficulty in breathing, along with pressure on the inside of my head, and some pain in my left arm. I responded by taking 200 to 400 mg of ibuprofen, which has eliminated some of the discomfort. The discomfort seems to be cyclic, getting worse and better on about a 20 minute cycle. I think this is a negative reaction to the medicine, and have quite taking the medication.