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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Constipation When With Cholangiocarcinoma?

My husband was diagnosed last month with cholangiocarcinoma and is currently going through chemotherapy. He is on extended release morphine sulphate for pain. Initially, he was taking Miralax to fend off constipation, but his doctor changed him to Senna and, unfortunately, is now experiencing constipation . . . the Senna is not working effectively for him and he has not voided his bowels in 3 days. This AM he took Miralax again, but has had no relief. He has taken several short walks, hoping the exercise would help, but nothing so far. What other recommendations might you have for the constipation? Another dose of Miralax?
Thu, 28 May 2015
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Pulmonologist,  's  Response
Thanks for your question on Health Care Magic.
I can understand your husband's situation and problem.
Probable causes of constipation in his case are morphine induced and low potassium (hypokalemia).
So better to get done potassium level and if low, supplements should be started.
Morphine is known to cause Constipation.
Fentanyl is newer opioid drug which is having higher pain relieving action with lower constipation.
So ask your doctor about this drug.
Ask your husband to drink plenty of fluids orally. Start high fiber diet with curd and yogurt to relieve constipation.
Hope I have solved your query.
Wishing good health to your husband.
Thanks.
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What Causes Constipation When With Cholangiocarcinoma?

Thanks for your question on Health Care Magic. I can understand your husband s situation and problem. Probable causes of constipation in his case are morphine induced and low potassium (hypokalemia). So better to get done potassium level and if low, supplements should be started. Morphine is known to cause Constipation. Fentanyl is newer opioid drug which is having higher pain relieving action with lower constipation. So ask your doctor about this drug. Ask your husband to drink plenty of fluids orally. Start high fiber diet with curd and yogurt to relieve constipation. Hope I have solved your query. Wishing good health to your husband. Thanks.