hi,
first of all
acne vulgaris is due to multifactorial apthogenesis, the following four factors: (1) follicular epidermal hyperproliferation with subsequent plugging of the follicle, (2) excess sebum production, (3) the presence and activity of the commensal bacteria
Propionibacterium acnes, and (4) inflammation.
Accutane (
Isotretinoin) has lot of side effects, some of them quite severe. Some of the common side effects would be dry mouth, nose, skin, lips, itching or conjuctivis while the severe ones include
bowel inflammation and pain, chest pain, decreased night vision, decreased tolerance to contact lenses, delay in
wound healing, depression, fatigue, headache, nausea, peeling palms or soles, rash, skin infections, stomach and intestinal discomfort, sunburn-sensitive skin, thinning hair, urinary discomfort, vision problems, vomiting, etc
spleen enlargement is not seen with isotretinoin.
alternative drus for acne is Cap Minocyclin 100 mg once daily.
hope this is helpful.
thanks