Hello thanks for asking from HCM for your health related queries I can understand your concern. Schizoaffective disorder is a psychotic disorder in which symptoms of both Schizophrenia and affective disorders are found in patients. Most of individuals suffering from Schizoaffective disorder function normally and respond to medicines if taken proper under prescription. Seroquel is Quetiapine and the drug is second generation antipsychotic. The drug can cause sedation, drowsiness, sleepiness, weight gain etc as side effect. Over all this doesn t interferes with thinking process. Lithium is a mood stabiliser drug. The drug is also not known to impair intelligence or thinking process. As per my opinion there is no need to worry. Continue to take your medicines as per your prescription and these medicines will help you in better functioning only. Thanks, I hope this helps you. Take care