I have had ITP chronic for almost two years. i also have Prostate Cancer and had 27 external beam radiation treatments. I was treated with predsione which did not work ,then given rubituxen . "Forgive my spelling" it work only a short time. I am now on Nplate which seems to work. My question is Nplate will bring my count up to at times over 300,000 then in 3or 4 days drop to 150 then in one or two days drop to the 30's. The trouble is i have internal Hemerroids which bleed when count drops. I went to emergency and they gave me platelets. which stoped the bleeding then got a nplate shot . My Hematologist told me not to go to hte emergency anymore and get Platelets because it does more harm then good in the long run. my HGB stays normal from 13.3 to 14.3 and all others are with in accable range. Is there anything else I can try. My dr. wnts me to have my spleen removed ,I am 69 yrs. and not confortable with doing that except as a last reasort. what is you take on my situation?