I ve been on omeprazole for a dozen years (reflux) and developed microscopic colitis about two years ago. No pain with the colitis, but very soft stool and occasionally diarrhea. Nothing has helped: I ve tried Entocort, laiada, bismuth, probiotics, lactose free diet (for about a month). Because the omeprazole may contribute to the colitis, I ve been urged to substitute pantoperazole or lanoperazole for the omeprazole. I ve been told that the former may be less likely to trigger the colitis than the omeprazole. Any suggestions?