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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What are the side effects of Prolia?

I AM 86 Yr. old female. Have, for many years now, SJOGREN S SYNDROME, FIBROMYALGIA, OSTEOSPOROSIS , RA, & LUPUS (Dr. thinks it s in remission). I have an extremely low energy level. I I m always extremely tired. Dr. gave me Plaquenil for Lupus, but because of all my autoimmune conditions, I lost my eyesight - developed TEMPORAL ARTIRITIS Haave had to take Prednisone for a few years. Now it sunder control. My question is: MY Rheumatologist wants to put me on PROLIA . The injection stays in the system 6 months. I m afraid of the side effects. Last time I took BONIVA (3 Mos.) & had a problem with dental work. Dentist refused to do dental work while Boniva was in my system. Would appreciate your input. Thank you. P.S. I also have Sleep Apnea
Mon, 20 Aug 2018
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General & Family Physician 's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

Prolia is composed of 'denosumab'. It is a human IgG2 monoclonal antibody. It is indicated for the treatment of post-menopausal women with osteoporosis at high risk for fracture. The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain and bladder infections. Low blood calcium (hypocalcemia) is one of the known side effects of Prolia. Intake of calcium and vitamin D would help prevent low blood calcium. Kindly take the medication as prescribed and do the necessary follow-up with your doctor as advised.

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