Hi Welcome to HCM. I appreciate your concern for the safety of Prednisone tablets. The common side effects associated with the use of Prednisone. Short-term effects (up to 3 weeks of therapy); Weight gain and fluid accumulation (oedema), increased blood sugar,decreased potassium level, gastrointestinal upset and ulceration, reversible depression of the hypothalamic-pituitary-adrenal (HPA) axis, and mood changes and abnormal behavior. Long-term effects (more than 3 weeks of therapy); Cushingoid appearance, abnormal facial hair growth, impotence, and menstrual irregularities, peptic ulcer disease, cataracts and increased intraocular pressure/glaucoma, myopathy, osteoporosis, and fracture spine. Regarding Humira (Adalimumab).. it is not given on daily basis, found to be more effective in the maintenance therapy. The commonly reported side effects include Immediate (infusion related): chills, rigors, joint pain and fever Late effects: risk of infection (re-activation of TB, pneumonia, etc) Hope this answers your query. If convinced with the explanation, kindly rate this answer by a feed back. Best regards.