Hi I had gone through your question and understand your concern. See ,the side effects of methotrexate are; You should check with your doctor immediately if any of these side effects occur when taking methotrexate: More common: Black, tarry stools blood in the urine or stools bloody vomit diarrhea joint pain reddening of the skin sores in the mouth or lips stomach pain swelling of the feet or lower legs Less common: Back pain blurred vision confusion convulsions (seizures) cough or hoarseness dark urine dizziness drowsiness fever or chills headache lower back or side pain painful or difficult urination pinpoint red spots on the skin shortness of breath unusual bleeding or bruising unusual tiredness or weakness yellow eyes or skin So , symptom which your suffering from is definitely not because of methotrexate. Let know what other medicines you are taking. I hope this information helps. Thankyou.