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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Side Effects Of Imatinib?

Hi, My father has undergone surgery for GIST in Oct 2014. From past three years he is taking Imatinib 400mg tablet everyday. My query is how does he need to use this tablet? Will there be any side effect of this if he continue taking it? Second query : Is Normocytic normochromic with mild anisocytosis is bad for him? Does Imatinib tablet causes the Heamoglobin to reduce? He has taken Actorize injections twice to improve his Heamoglobin and blood count. Is it oksy to take Actorize and Imatinib tablet?
Tue, 27 Feb 2018
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General & Family Physician 's  Response
Hi & Welcome.
I appreciate your concern for your father.
Imatinib (tyrosine kinase inhibitor) is commonly prescribed to treat certain types of leukemia (cancer that begins in the white blood cells) and gastrointestinal stromal tumors (GIST).

It is usually taken with a meal and a large glass of water once or twice a day. The tablets should not be crushed and have to be taken at around the same time(s) every day exactly as prescribed by his doctor.

Its common side effects include: stomach upset, nausea/vomiting, diarrhea, headache, muscle/joint pain, muscle cramps, dizziness, blurred vision, or drowsiness. It may also cause anemia (decreased hemoglobin), leucopenia (decreased white blood cells) and thrombocytopenia (decreased platelet counts).

So, normocytic normochromic anemia with mild anisocytosis appears to be due to one of the side effects of Imatinib, it can be prevented by giving Actorize injections which help to increase his hemoglobin level and thus can prevent normocytic normochromic anemia.

There's no harmful interaction between Imatinib and Actorize hence they can be taken.

Hope these answer your queries.
Wishing your father a very good health.
A feed back is appreciated.
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What Are The Side Effects Of Imatinib?

Hi & Welcome. I appreciate your concern for your father. Imatinib (tyrosine kinase inhibitor) is commonly prescribed to treat certain types of leukemia (cancer that begins in the white blood cells) and gastrointestinal stromal tumors (GIST). It is usually taken with a meal and a large glass of water once or twice a day. The tablets should not be crushed and have to be taken at around the same time(s) every day exactly as prescribed by his doctor. Its common side effects include: stomach upset, nausea/vomiting, diarrhea, headache, muscle/joint pain, muscle cramps, dizziness, blurred vision, or drowsiness. It may also cause anemia (decreased hemoglobin), leucopenia (decreased white blood cells) and thrombocytopenia (decreased platelet counts). So, normocytic normochromic anemia with mild anisocytosis appears to be due to one of the side effects of Imatinib, it can be prevented by giving Actorize injections which help to increase his hemoglobin level and thus can prevent normocytic normochromic anemia. There s no harmful interaction between Imatinib and Actorize hence they can be taken. Hope these answer your queries. Wishing your father a very good health. A feed back is appreciated.