Hi, Thanks for posting in HCM. Berbesta contains an ingredient called Berberine , a chemical found in several plants. People take berberine for heart failure. Herbs containing berberine have been used in Chinese medicine to treat diabetes for thousands of years. It is thought that berberine can help lower cholesterol levels in people with high cholesterol. People apply berberine directly to the skin to treat burns and to the eye to treat bacterial infection trachoma. Berberine extract has been shown to help individuals who have PCOS. Berbista is not known to have effect on weight reduction directly. Berberine is possibly safe for most adults for short-term use when taken orally or applied to the skin. Possible side effects with its use could be decreased blood sugar or blood pressure. Since you are having associated thyroid illness, you need to take prescribed medication lifelong. Only thing is your dosage can be reduced based on your response to medication by doing regular thyroid profile tests. Since you have two different issues related to thyroid and ovaries, if you want to conceive, you need get treated appropriately for both these conditions. Kindly consult Gynecologist in this regard for appropriate management. Hope the information provided would be useful. Wish you good health.