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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Effects Of Cortisone On Fetus During Pregnancy?

My Mother has had Rheumatoid Arthritis for over thirty years, and before she was pregnant with me she was convinced to go to Mexico to see doctors there that put her on a number of drugs. One of which was cortisone. It wasn’t until she got back and had me, she saw an internal medicines specialist and found out she was on 60 – 100 mg of cortisone a day. She was on this high level of cortisone throughout her entire pregnancy with me. Cortisone is a corticosteroid and is closely related to Cortisol and other steroids such as Aldosterone. So my question is; what can a high dose of Cortisone do to a Fetus? Could it take a genetically (XX) Female, that without any interference would develop fully as a girl, and cause it to develop as a fully functioning male? Could it cause androgens to develop the wolffian ducts to be stimulated into growth rather than the Development of müllerian ducts? Then the fetus develops into a male baby. My entire life I have felt like a female spirit trapped in a male body. I am just trying to figure out why I feel the way I do. Please, any information or help you can give would be appreciated,
Mon, 24 Aug 2015
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General & Family Physician 's  Response
Hello
Thank You for contacting HCM.

I read your query carefully;
There is no such evidence.
Negative fetal effects of antenatal corticosteroids are a reduction of fetal body and breathing movements and a reduction of fetal heart rate variation, without any changes in Doppler waveform patterns of fetoplacental vessels. It has been suggested that a multiple course of corticosteroids antenatally might induce negative effects on fetal intrauterine growth and on neonatal birth weight.
In addition, multiple courses are associated with an increased risk of early-neonatal sepsis.
So you should not think like this.
This is misconception.
Hope this answers your question. If you have additional questions or follow
up questions then please do not hesitate in writing to us.
Wishing you good health.
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What Are The Effects Of Cortisone On Fetus During Pregnancy?

Hello Thank You for contacting HCM. I read your query carefully; There is no such evidence. Negative fetal effects of antenatal corticosteroids are a reduction of fetal body and breathing movements and a reduction of fetal heart rate variation, without any changes in Doppler waveform patterns of fetoplacental vessels. It has been suggested that a multiple course of corticosteroids antenatally might induce negative effects on fetal intrauterine growth and on neonatal birth weight. In addition, multiple courses are associated with an increased risk of early-neonatal sepsis. So you should not think like this. This is misconception. Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. Wishing you good health.