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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What are the effects of IGa deficiency?

I am IGa deficient. 49 years ago my daughter was born with IGa deficiency. My daughter 53 and son 45 are both normal IGa.



About 40 years ago (I was not aware of IGa) I donated blood. Since I worked in the lab I was aware that the recipient had a reaction to the blood. - The lab went crazy rechecking all availble factors. -



A few years later the same thing happened.



I have not donated blood since but am curious if the IGa could be the cause of these reactions.



I am told to have washed cells only as a recipient but I couldn't have developed anti-bodies.



What is your opinion.



My daughter and one grandaughter would like to know also.



Phyllis Dubey



Thu, 6 Nov 2014
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Hematologist 's  Response
Hi, dear
I have gone through your question. I can understand your concern. You have iga deficiency. So you may have anti iga antibodies in your blood. It hives reaction with iga. When you take washed rbc there is no reaction, because washed rbc doesn't contain iga.
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