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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What are the available treatments for Anti-thrombin III deficiency?

My niece is living w/a blood clot running from her belly button to her knee. She developed this almost 7 years ago after delivery and was diagnosed w/anti-thrombin III (it now is assumed that this caused her father s early death). Are there any new treatments for this deficiency?
Tue, 18 Feb 2014
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Infectious Diseases Specialist 's  Response
Hello,
Welcome to HCM
As your niece is suffering from anti-thrombin III deficiency,and also she has a blood clot,she needs anticoagulation.
Warfarin-oral anticoagulant is the drug of choice.
Nowadays,low molecular weight heparins like argatroban and antithrombin III concentrates are also tried for this disease.
These drugs are given lifelong to protect from recurrent Venous Thromboembolic Episodes.These drug therapy should be monitored very closely,as there are many side effects from this.
Also, i would suggest your niece to avoid a variety of precipitating factors, such as taking oral contraceptives or hormone replacements, that may precede the development of Venous Thromboembolic Episodes.
Hope i have cleared your doubts.
Thank you.
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What are the available treatments for Anti-thrombin III deficiency?

Hello, Welcome to HCM As your niece is suffering from anti-thrombin III deficiency,and also she has a blood clot,she needs anticoagulation. Warfarin-oral anticoagulant is the drug of choice. Nowadays,low molecular weight heparins like argatroban and antithrombin III concentrates are also tried for this disease. These drugs are given lifelong to protect from recurrent Venous Thromboembolic Episodes.These drug therapy should be monitored very closely,as there are many side effects from this. Also, i would suggest your niece to avoid a variety of precipitating factors, such as taking oral contraceptives or hormone replacements, that may precede the development of Venous Thromboembolic Episodes. Hope i have cleared your doubts. Thank you.