Hi, Thanks for writing, First, i hope you realize that the cause of pain should be removed to permanently cure it. So a visit to a dentist is mandatory. Secondly, combiflam has to be taken every 6-8 hours to a maximum of 4 tablets a day. There are long acting pain killers available, which will relieve you with pain in a single daily dose like tramadol extended dose or long acting acetaminophen. Please visit your dentist and don t just take pain killers without prescription. As you understand the adverse effects related to them. Stay healthy, Thank you.