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Taking medication for hyperthyroidism. Feeling pregnant. Side effect of medicine on pregnancy?

Hi Doctor , i have a hyper thyroid & im on neo mercazole 5mg & Inderal medications now for the past 2 years.Currently im taking 2 pills of neo mercazole & 2 pills of Inderal , i have been trying to get pregnant lately with no luck , however i have a missed period ( 2 days only ) & i feel like pregnant but im afraid the medications might have affected the baby during the past 2 weeks , could you plz advise about possible side effects during 1st 2 weeks of pregnancy .Im intending to take a blood test tomorow, wish me luck.
Asked On : Mon, 31 Dec 2012
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General & Family Physician 's  Response
thank you.neomarcazole can be used during pregnancy period but it is better to avoid it. it causes a cutaneous manifestation to fetus called aplasia cutis. the suitable alternative is propylthiouracil which cross the placental barrier and treat fetal thyrotoxicosis also. you have to continue this drug during breasting because neomarcazole is contraindicated during that it is a time to repeat thyroid function & consult a endocrinologist.
Answered: Mon, 31 Dec 2012
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Psychiatrist Dr. Jonas Sundarakumar's  Response
Hello and welcome to Healthcare Magic. Thanks for your query.

Neo-Mercazole (Carbimazole) is used in the treatment of hyperthyroidism. The drug is permitted to be used during pregnancy, but needs to be taken in the minimum effective dosage. High doses can have a risk of causing neonatal hypothyroidism and goitre. In very rare cases, there is possibility of a congenital abnormality called aplasia cutis in neonates. If dose is in the minimum range and the thyroid status of patient is regularly monitored, there is no major effect on the unborn baby. In fact the possibility of congenital malformations in babies born to untreated mothers suffering from hyperthyroidism is more than those treated with Neo-Mercazole.

Inderal (Propranolol) has been assigned to pregnancy category C by the FDA. This means that some animal studies using high doses have revealed evidence of embryotoxicity, but there is no evidence of embryotoxicity in humans.

In case you suspect that you could be pregnant then you can start off folic acid supplements right away. Further decisions regarding your thyroid medication can be later discussed with your endocrinologist.

Wish you all the best.

Dr. Jonas Sundarakumar
Answered: Mon, 31 Dec 2012
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