DEAR SIR/MADAM TABLET CUDO FORTE CONSISTS OF PRE AND PROBIOTIC CONTENTS SUCH AS STREPTOCOCCUS THERMOPHILUS LACTOBACILLUS ACIDOPHILUS BIFIDOBACTERIUM LONGUM LACTILOL MONOHYDRATE THESE COMPONENTS ARE ADEQUATELY BALANCED SO THAT THESE PROBIOTIC MICROBES USES UREMIC TOXINS AS NUTRIENT THAT IS YOUR UREA AND CREATININE AND USES IT TOXIN/MICROBES AND METABOLITES ARE ELIMINATED AS SOLID WASTE THUS REDUCING BURDEN OF UREMIC TOXINS. SO BY USING CREATININE AS FOOD THESE MICROBES WILL REDUCE IT. AS WHEN YOU LEAVE THESE TABLETS SLOWLY IT WILL RAISE THE CREATININE LEVELS.