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Swollen vaginal labia. Taking methotrexate for psoriasis, penicillin for tonsillitis. Causes?

Hi there, before I go into my symptoms, I had better tell you the drugs I m on to see if any of those are responsible? I started taking methotrexate 5 weeks ago( psoriasis sufferer) ....just recently had tonsillitis to which I m on day 4 of penicillin the labia s are hot and swollen and very sore it s painful and don t know what it is....any ideas?
Asked On : Mon, 24 Dec 2012
Answers:  1 Views:  279
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General & Family Physician 's  Response
Hi jessiekinnin welcome to HCM,
Penicillin interferes with the excretion of methotrexate by kidney and thereby increasing the concentration of methotrexate in the blood and thus causing more serious side effects like lung, liver damage, decrease in blood cell counts etc. So the blood levels of methotrexate should be monitored if penicillin is taken along with and should be adjusted accordingly.. But the interaction cannot produce swollen and painfull vagina..
It may occur as an allergic reaction to penicillin per se and it is rare...
This condition is called vulvovaginitis which may be due to variety of other reasons like infections, inflammation, allergy, swollen glands in the vagina etc. which needs to be evaluated..
With regards
Answered: Mon, 24 Dec 2012
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