Hello Doctor, I was recently hospitalized for major depression with psychosis for the first time in my very long (and seemingly hopeless) battle with depression/psychotic depression, anxiety and panic attacks. I was released on Friday 5/15/2015. In addition to changing the times and dosages of the medications my regular Psychiatrist had me currently taking (5mg Klonopin (to 2.5mg), 200mg Lamotrigine (to 300mg), 250mg Nuvigil, 120mg DULoxetine (to 60mg) and most recently ?mg Seroquel XR), the Doctor in charge of my care removed Nuvigil from my regime, changed Seroquel XR to 200mg QUEtiapine Fumarate and added (PRN) 25mg hydroxazine several times a day as needed. I also take otc (PRN) 600mg Motrin and 150mg Tylenol for my constant RA and OA pain. Upon my discharge I was given prescriptions for all of the medications except for the hydroxizine and now I am having a constant amount of mid-level anxiety with some pretty intense episodes. The hydroxizine seemed to help alot with the anxiety and I felt much better and calm in general without feeling drowsy even though I still had/have rapid mood swings, and at the same time my body is trying to adjust to the new regime to level out which has yet to happen :( But is it a safe medication to take on a regular basis? The nurse told me I could buy any antihistimine otc and it would do the same thing so I bought Unisom Sleep Tabs (25mg Doxylalmine) because I can t take diphenhydromine as it has always made me jittery and more anxious and now I ve found that the Doxylamine makes me sleepy and gives me a headache. I don t know what to do but I have to do something as the anxiety isn t subsiding at all. I always feel like I m over-reacting and don t want anyone to think I m drug-seeking because I m not but I don t know whether to ride it out a few more days until I see my regular Dr. but the longer I m anxious, the worse it gets. I feel like I ve been spinning my wheels for way too long. Should I call the Dr. that was in charge of my meds in the hospital or my regular Psychiatrist? Is hydroxizine safe to take with all of my other medications? Any input, advise or opinion would be greatly and sincerely appreciated. Thank You, Priscilla