Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Constipation for a long time should be investigated further. I would advise such a patient the following: Get a colonoscopy and CT scan of abdomen to rule out any cancer, mass, ulcer, stricture and so on. This helps to find out the cause. Also go for stool test for three days, it helps in some cases. Change over to another stool softeners and laxatives to see the one that is most helpful and suitable too. Regular tests of Vitamin D and other vitamins to get corrected by an appropriate supplements is most needed. Get an opinion of a Neurologist for yourself to find out any earliest symptom or sign of Parkinson s disease. Hope I have answered your query. Let me know if I can assist you further.