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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Pulmonary Embolism In The Lung

I HAD A CLOT GO TO MY RIGHT LUNG AND WAS PUT ON LENOVAL INJECTION FOR 7 DAYS AND 5 MG WARFARIN FOR THREE MONTHS,,,,I WAS TAKING 500 MG PHENYTOIN A DAY AND WAS CUT BACK TO 100 MG A DAY..WILL THIS MESS UP MY DILANTIN LEVEL AND PUT ME A THE RISK FOR A SEIZURE...MY LEVEL STAYS AROUND 12 AND LAST SEIZURE WAS IN 2004
Wed, 8 Jul 2015
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Pulmonologist,  's  Response
Thanks for your question on Health Care Magic.
I can understand your situation and problem.
Phenytoin is having drug interaction with warfarin.
So both will interact with each other and decrease their therapeutic levels.
And hence desired anti epileptic and anti coagulant effect can not achieved.
So possibility of seizure attack and recurrence of Pulmonary embolism is high.
So in my opinion, you should continue warfarin. Better to start newer anti epileptic drug. Newer drugs are having less interactions and more effectiveness.
So better to consult your epilepsy doctor and discuss about changing phenytoin to avoid drug interactions with warfarin.
Hope I have solved your query.
I will be happy to help you further. Wish you good health. Thanks.
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Suggest Treatment For Pulmonary Embolism In The Lung

Thanks for your question on Health Care Magic. I can understand your situation and problem. Phenytoin is having drug interaction with warfarin. So both will interact with each other and decrease their therapeutic levels. And hence desired anti epileptic and anti coagulant effect can not achieved. So possibility of seizure attack and recurrence of Pulmonary embolism is high. So in my opinion, you should continue warfarin. Better to start newer anti epileptic drug. Newer drugs are having less interactions and more effectiveness. So better to consult your epilepsy doctor and discuss about changing phenytoin to avoid drug interactions with warfarin. Hope I have solved your query. I will be happy to help you further. Wish you good health. Thanks.