Dear Patient, Masturbation differs from real sexual intercourse with a female. It is a new experience for you with your female partner,therefore,your very high level of sexual excitement and anxiety can cause your premature ejaculation. This is absolutely normal and you will overcome it when you have more sexual experiences with your partner. Also you can follow Masters and Johnson guidelines to delay premature ejaculation. It means you or your partner can stimulate you but at the moment of ejaculation you or your partner can stop stimulation by gently squeezing the head of the penis. After a while you can again start the stimulation and stop it just before ejaculation. This will help you to extend your foreplay and delay your ejaculation. Also if the course of your premature ejaculation related to stress or anxiety, you can do breathing exercises to relax yourself. If you are needed SSRI inhibitors like Fluvoxamine to treat anxiety related conditions that has to be prescribed by a physician only. However, I believe by talking to your partner and practicing above mentioned pause-squeeze techniques is the best way to solve this problem without medication. I hope you won t need medication and those techniques will help you to overcome your problem. Good Luck! Dr. Dinesh Weerasinghe MD.