Dear Madam, Hi & Welcome. Name of the prescribed medication?? I ve gone through your history and sorry to know about the discomfort you had with the medications prescribed for overactive bladder. Since most of the drugs used in the treatment of overactive bladder are anticholinergics which can cause dry mouth, blurring of the vision, increased heart beats and constipation as their side effects. Since constipation is annoying you too much so I would advise you to take a fiber rich diet or stool softener along with the medication. You can also try Imipramine (a tricyclic antidepressant) which also relaxes bladder muscles with a less tendency to cause constipation. Besides medication I also suggest some lifestyle changes like: 1. Avoiding drinking caffeine, alcohol or a lot of fluids before activities 2. Not drinking fluids right before you go to bed 3. Bladder training. This is the most common natural remedy that doesn’t involve medication. It helps change the way you use the bathroom. Instead of going whenever you feel the urge, you urinate at set times of the day, called scheduled voiding. You learn to control the urge to go by waiting for a few minutes at first, then gradually increasing to an hour or more between bathroom visits. 4. Pelvic floor exercises to strengthen the muscles that control urination. During these pelvic floor exercises also called Kegels, you tighten, hold, and then relax the muscles that you use to start and stop the flow of urination. 5. Wearing absorbent pads can help hide any leakage that occurs. 6. Maintain a healthy weight. If you re overweight, losing weight may ease the symptoms. Regarding Botox; it is a toxin produced by the bacteria that cause botulism illness. It can be used in small doses directly injected into bladder tissues, causing partial paralysis of the bladder muscles. The effects are temporary, lasting only about six to nine months. Clinical research shows that it may be useful for severe urge incontinence. However, it s not approved by the Food and Drug Administration for this purpose in people without neurological disease. This medication also carries a risk of worsening bladder emptying in older adults and people already weakened by other health problems. If you re considering Botox treatments, you should be willing and able to catheterize yourself if urinary retention occurs. Hope the advice given above would be useful in getting relief from the symptoms of overactive bladder. A feedback is appreciated.