Hello. Lyme disease scares a lot of people and doctors often disagree about what to do about it. The answer to this question is not simple. First of all, it depends on where you live. If you live somewhere where Lyme is very common like the Northeast United States then you may be likely to get infected over and over. This is why it is important to protect yourself with ticks with clothing and repellent and also to check yourself for ticks regularly (I suggest in the shower). Lyme can come back if you are reinfected and it needs to be treated each time. I don t believe there is any evidence it would get worse each time or that it would be more likely to go to your brain. Lyme meningitis (when it goes to your brain ) is something that would start with symptoms usually and can be treated just like Lyme in other stages. I wouldn t be scared but at this point I would consider seeing an infectious disease doctor for their opinion as it s sometimes hard to sort these things out by a primary care doctor. Certainly if you have fever, neck stiffness, muscle aches or other signs of Lyme you should be seen sooner than later. Take care, Dr D