Hi Dr. Grief, I had a total hysterctomy in early December 2013. I was 34 at the time and was seeking relief from grade 4 endometriosis. My doctor put me on Premarin .625mg right after surgery. I was still having 3-6 hot flashes/day and night sweats. I was also having trouble sleeping. My biggest concern, however, is bone and joint pain--especially in my shins, calcaneal bones, and the small bones of my feet. I started to experience more excessive bone/joint pain in March, and it s progressively become worse. Sometimes, it s sharp when I step a certain way. I told my doctor and they did blood work. It all came back normal. I m a chiropractor, and I went so far as to do x-rays of my knees and my tibias. I didn t see anything remarkable. This week, I am having a body scan because the pain is so worrisome to me. I ve always been a VERY active person. In the past, I ran 5 days/wk and lifted weights. I ve had shin splints in the past, but this doesn t feel like that. Could this be a side effect of low estrogen? I did trying switching to Climara for a month to see if a different form of estrogen would improve my symptoms. It improved my hot flashes, but not my joint and bone pain. Just looking for an answer to the pain. My doctor just says, well, your blood work is all normal. I don t know what to tell you. Very frustrating.