I am a renal transplant patient. Surgery done 6 months back. After transplatation I used to take immuno suppresents like Pangraf, Cellcept and Prednisolon. Immediate after surgery my S.Creatin levels were 1.4, 1.3, 1.2 then 1.5 etc..After one month of when I checked my Tac level it was very high ie, 14.4. Then Pangraf dosage reduced for next one month.But there was no significant reduction in Creatin and then checked Tac level it shows 14.1. At that time S.Creatin was 1.7.Then stopped Pangraf and started Certican .25. A sudden increase in S.creatin and it became 2.6. My Biopsy shows ATN+ and other readings were quite normal. My Potassium and RBS are quite normal. Then started Neoral 50mg and tried 25mg, but again S.creatin level gets increased and now it is 3.6. My Doppler test parameters are normal. What would be the remedy on this problem??How it is happened like this? My donor is my brother. I am 42 Years old.