hi, my son has the following results and symptoms and would like to know what you think: At around 1 year of age George developed eczema with an unknown trigger. At 3 years of age he had a spell of wheezing when visiting friends who have a dog, and this re-occurred on subsequent visits. From age 4 onwards he began experiencing coughing, sneezing, wheezing, itchy eyes and congestion when going outdoors in spring and late summer. On numerous occasions between 6 and 9 years George had emergency breathing problems when going out in cold weather and especially during exercise. He had a cystic fibrosis sweat test, which came back negative. Wheal-and -flare responses were observed in response to dog dander and pollen. Full blood count: RBC = 4.0 x 1012/l, WBC = 13.0 x 109/l, Hb = 12.9 g/dl. Differential leucocyte count: Neutrophils 60%, Lymphocytes 20%, Eosinophils 1200/microlitre Lymphocyte enumeration: CD3 +ve cells 70%, CD19 +ve cells 15%, CD4 +ve cells 41%, CD8 +ve cells 25%. CH50 Total haemolytic complement: 130 haemolytic units Complement components: C3 1.1 g/l, C4 0.2 g/l Immunoglobulin and antibody tests: Serum IgG 1000mg/dl, IgM 180mg/dl, IgE 1750 IU/ml ( 150KUA/litre, or 20mg/dl), RAST positive (score 6) for dog dander and pollens. Thank you