My 19 year-old son has been treated for bipolar depression for a year being treated with 1 mg respiradole. For the past three months his depression has resurfaced but developed uncontrollable laughter. he has hospitalized for a week, concerta and Zoloft, which he refuses to take. they had him taking 25 md Concerta and Zoloft which made him feel bad. His liver levels are abnormal for past year. which medicine is safe and should the dr have kept him in the hospital and gradually placed him on the meds starting at a lower dose? His laughing is all day long, throughout the evening, along with depression.