Hi, My wife is undergoing treatment for Acute Myeloid Leukemia, as a consequence of successful chemo/radiotherapy for inflammatory breast cancer. Prior to the onset of the breast cancer, she had been treated for Hepatitis C (100% cure - zero detectable virus) with chronic fatigue syndrome as the result of the interferon/ribavirin therapy. Following the hep therapy, she was finally diagnosed with a low cortisol output, which explained the CFS. However, now in day 17 of the AML, she has tachycardia of 145 - 150, intermittent fevers of 101 - 102.5, and delirium. I suggested there might be a link between circulating cytokine levels, specifically IL-1, IL6 and TNF alpha, and the inability of the adrenal cortex to respond accordingly, but the oncologist basically called me an idiot and became angry that I was going off on a tangent. Can you advise if my theory merits consideration? thank you - Richard