Hello thanks for asking from HCM
You have MDD or major depressive episode. You have tried medicines like Citalopram, Escitalopram,
Sertraline, Buspirone,
Venlafaxine etc drugs and only Venlafaxine resulted in improvement but it caused anxiety. Now the symptoms are persistent and you have stopped to take medicines since last 5 years.
First of all I would like to advise you to visit your
psychiatrist again and start taking medicines again. You have MDD and without medicines the symptoms will become more and more severe. If these medicines failed to work then other medicines like
Mirtazapine can be used. The medicine will also help in sleep and will help in depressive symptoms. Augmentation with drugs like
Lamotrigine, Lithium can help in resistant depressive symptoms. Visit your psychiatrist for prescription of these drugs.
For resistant depression brain stimulation methods like electro convulsive therapy, Vagal Nerve Stimulation, RTMS (trans cranial magnetic stimulation) etc prove useful supplement to medicines.
Thanks, hope this helps you