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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For JC Virus Infection

I HAVE HAD MS FOR 14 YRS. I HAVE BEEN ON TYSABRI FOR 2 YEARS. I TESTED NEGATIVE FOR THE Jc virus INITIALLY BUT LAST MONTH I TESTED POSITIVE. MY DR WANTS TO RETEST ME AND I MAY HAVE TO GO TO A DIFFERENT MS TREATMENT BECUASE OF THE OBVIOUS RISK OF PML. I HAVE BEEN ON AVONEX, COPAXONE, REBIF AND BETASERONE AND THE TYSABRI HAS WORKED WONDERS..NO NEW LESIONS AND NO SIDE EFFECTS. I WAS ALSO JUST DIAGNOSED WITH UCTD AND WILL START ON PLEQUENIL NEXT WEEK. WHAT ALTERNATIVE MS TREATMENT SHOULD WE EXPLORE? AND IS IT COMMON TO GET UCTD WHEN YOU ALREADY HAVE MS?
Mon, 5 Dec 2016
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General & Family Physician,  's  Response
Thank you for query.You can the following suggestions
1.DO an LIVER FUNCTION TEST,because the MS drugs affects liver.Your UCTD symptoms can be due to your liver problems.
a COMPLETE HEMOGRAM should also be done.
2.Your current MS therapy is a good recommendation.ARA-C and MEFLOQUINE is tried in case of PML,BUT ONLY after confirmation of the diagnosis.we found many asymptomatic cases of JC virus infection in our community(50-80%).So PML and JC virus infection are not always co-exist together if your immune system is not compromised.

Liver is a very important organ,it synthesizes many antibodies,protective bio molecules.Your immunity can be hampered if liver is affected.

3.Avoid alcohol,smoking.Take antioxidant capsules.Take soribilin.test for pml as per your doctor recommendation.continue ms and uctd treatment as well. do an LFT and CBC.

DONT WORRY.HOPE FOR THE BEST.
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Suggest Treatment For JC Virus Infection

Thank you for query.You can the following suggestions 1.DO an LIVER FUNCTION TEST,because the MS drugs affects liver.Your UCTD symptoms can be due to your liver problems. a COMPLETE HEMOGRAM should also be done. 2.Your current MS therapy is a good recommendation.ARA-C and MEFLOQUINE is tried in case of PML,BUT ONLY after confirmation of the diagnosis.we found many asymptomatic cases of JC virus infection in our community(50-80%).So PML and JC virus infection are not always co-exist together if your immune system is not compromised. Liver is a very important organ,it synthesizes many antibodies,protective bio molecules.Your immunity can be hampered if liver is affected. 3.Avoid alcohol,smoking.Take antioxidant capsules.Take soribilin.test for pml as per your doctor recommendation.continue ms and uctd treatment as well. do an LFT and CBC. DONT WORRY.HOPE FOR THE BEST.