Hi,Dear,Thanks for your query to HCM virtual Clinic. I studied your query in all the details put forth by you. I understood your health concerns. Cause of the health problems you queried- There are many causes of the lumps on your left legs,thighs and ankle. AS I have very little information as to how it started/any wound to start with?Any itching?With whose advise you are on Atarax?I would not be able to comment on its treatment exactly. Any local pain on the lumps/Swelling and redness along the vessels up the leg and thighs? To rule out these things I would advise you to consult ER surgeon, who would examine it and treat it accordingly. Cause in your case- As the lump has started 2 weeks back in the left ankle,it seems that you had some un-noticed wound in the left ankle,which grew into legs and thighs along the vessels up the leg. With the above data,you seem to suffer from- Bruise/bite/wound of the left ankle with cellulitis and thrombophlebitis,spreading to legs and thighs? Remedy- In the absence of more information,I would advise Second opinion in your case, who would examine it and investigate it to treat it as per the cause of the lump. In the meanwhile treat as follows- Cold Compresses. Thrombophobe/ Voltaren oint/gel to reduce the swelling, Tab Voltaren(anti-inflammatory)if the pain is more and unrelieved by above steps of care Antibiotics with the advise of your treating Surgeon. So I would advise you to consult ER Surgeon , who would rule out other causes of such a lump and would help you out with the fist hand information. Do take his Second Opinion, on the above suggestion,as he would advise you with fist hand clinical information. Hope this would resolve your query with full satisfaction. Welcome for any further query in this regard to ME by direct question at HCM. Write excellent review and hit thanks, to narrate your experience ,which would improve my rating for many other visitor s to HCM. Wishing you fast recovery. Have a good day. Dr.Savaskar M.N. Senior Surgical Consultant. M.S.Genl-CVTS